Drug interactions
Safinamide + Ziprasidone
Severity: Moderate
Safinamide and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone blocks dopamine D2 receptors and can counteract the dopaminergic benefit of safinamide in Parkinson disease. This may worsen motor symptoms and reduce the benefit of treatment.
What this interaction means in plain words
Safinamide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Safinamide belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between a D2 receptor antagonist and a dopaminergic agent.
What to do
Avoid ziprasidone in Parkinson disease; if an antipsychotic is needed, use quetiapine or clozapine. Monitor motor function if the combination cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Safinamide and Ziprasidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Ziprasidone?
MediHelp rates the interaction as moderate. Safinamide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone blocks dopamine D2 receptors and can counteract the dopaminergic benefit of safinamide in Parkinson disease. This may worsen motor symptoms and reduce the benefit of treatment.
How serious is the interaction between Safinamide and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ziprasidone in Parkinson disease; if an antipsychotic is needed, use quetiapine or clozapine. Monitor motor function if the combination cannot be avoided.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
