Drug interactions
Sage + Tapentadol
Severity: Minor
Sage and Tapentadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some sage species have been reported to have sedative or CNS-modulating properties, which could add to the drowsiness caused by tapentadol. Evidence for a real clinical effect is limited.
What this interaction means in plain words
Sage and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; mechanism not well established.
What to do
Advise patients to watch for increased drowsiness when taking medicinal quantities of sage with tapentadol. Stop the herbal product if sedation becomes troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Frequently asked questions
Can I take Sage with Tapentadol?
MediHelp rates the interaction as minor. Sage and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some sage species have been reported to have sedative or CNS-modulating properties, which could add to the drowsiness caused by tapentadol. Evidence for a real clinical effect is limited.
How serious is the interaction between Sage and Tapentadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for increased drowsiness when taking medicinal quantities of sage with tapentadol. Stop the herbal product if sedation becomes troublesome.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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