Drug interactions
Albuterol + Sevoflurane
Severity: Moderate
Albuterol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval, and high-dose or systemic albuterol may cause tachycardia, hypokalemia and arrhythmias. Together they may increase the risk of ventricular arrhythmia, mainly with systemic use or large inhaled doses.
What this interaction means in plain words
Albuterol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on repolarization and beta-2 mediated hypokalemia and tachycardia that promote arrhythmia.
What to do
Monitor ECG and serum potassium in patients receiving frequent or high-dose albuterol. Correct hypokalemia before and during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Albuterol with Sevoflurane?
MediHelp rates the interaction as moderate. Albuterol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval, and high-dose or systemic albuterol may cause tachycardia, hypokalemia and arrhythmias. Together they may increase the risk of ventricular arrhythmia, mainly with systemic use or large inhaled doses.
How serious is the interaction between Albuterol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients receiving frequent or high-dose albuterol. Correct hypokalemia before and during anesthesia.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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