Drug interactions
Salbutamol + Vemurafenib
Severity: Moderate
Salbutamol and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval in a concentration-dependent way. Salbutamol may add to arrhythmic risk through hypokalemia and increased heart rate, particularly at high doses.
What this interaction means in plain words
Salbutamol and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Salbutamol belongs to Respiratory; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia and sympathetic stimulation contributing to arrhythmic risk.
What to do
Obtain ECG and electrolytes at baseline and periodically, correcting potassium and magnesium. Limit salbutamol to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Salbutamol and Vemurafenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Salbutamol
Other interactions of Vemurafenib
Frequently asked questions
Can I take Salbutamol with Vemurafenib?
MediHelp rates the interaction as moderate. Salbutamol and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib can prolong the QT interval in a concentration-dependent way. Salbutamol may add to arrhythmic risk through hypokalemia and increased heart rate, particularly at high doses.
How serious is the interaction between Salbutamol and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and electrolytes at baseline and periodically, correcting potassium and magnesium. Limit salbutamol to the lowest effective dose.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
