Drug interactions
Salbutamol + Vorinostat
Severity: Moderate
Salbutamol and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation and electrolyte disturbances. Salbutamol can lower serum potassium and raise heart rate, increasing the risk of arrhythmia.
What this interaction means in plain words
Salbutamol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Salbutamol belongs to Respiratory; Vorinostat belongs to Oncology.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia contributing to arrhythmic risk.
What to do
Monitor ECG, potassium and magnesium, and correct abnormalities. Use the lowest effective salbutamol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Salbutamol with Vorinostat?
MediHelp rates the interaction as moderate. Salbutamol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation and electrolyte disturbances. Salbutamol can lower serum potassium and raise heart rate, increasing the risk of arrhythmia.
How serious is the interaction between Salbutamol and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium, and correct abnormalities. Use the lowest effective salbutamol dose.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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