Drug interactions
Salmeterol + Ziprasidone
Severity: Moderate
Salmeterol and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, with ziprasidone having a well-recognized effect and salmeterol contributing via beta-2 mediated hypokalemia and tachycardia. The combination may raise the risk of ventricular arrhythmias, especially with other risk factors.
What this interaction means in plain words
Salmeterol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Salmeterol belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and beta-agonist related hypokalemia and increased heart rate.
What to do
Check baseline ECG and electrolytes in patients with cardiac risk factors, and monitor QTc and potassium during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Salmeterol with Ziprasidone?
MediHelp rates the interaction as moderate. Salmeterol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, with ziprasidone having a well-recognized effect and salmeterol contributing via beta-2 mediated hypokalemia and tachycardia. The combination may raise the risk of ventricular arrhythmias, especially with other risk factors.
How serious is the interaction between Salmeterol and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac risk factors, and monitor QTc and potassium during co-therapy.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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