Drug interactions
Salsalate + Vitamin k1
Severity: Minor
Salsalate and Vitamin k1: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose salsalate may impair clotting factor synthesis and, to a lesser degree than aspirin, affect platelet function, which could oppose phytonadione. The clinical effect is usually modest.
What this interaction means in plain words
Salsalate and Vitamin k1 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate may reduce vitamin K-dependent clotting factor synthesis at high doses.
What to do
Monitor INR or bleeding signs if salsalate is given at high doses to a patient being treated with phytonadione.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin k1
- Vitamin k1 + Warfarin Major
- Cholestyramine + Vitamin k1 Moderate
- Colestipol + Vitamin k1 Moderate
- Ketorolac intranasal + Vitamin k1 Moderate
- Mineral oil + Vitamin k1 Moderate
- Orlistat + Vitamin k1 Moderate
Frequently asked questions
Can I take Salsalate with Vitamin k1?
MediHelp rates the interaction as minor. Salsalate and Vitamin k1 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High-dose salsalate may impair clotting factor synthesis and, to a lesser degree than aspirin, affect platelet function, which could oppose phytonadione. The clinical effect is usually modest.
How serious is the interaction between Salsalate and Vitamin k1?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR or bleeding signs if salsalate is given at high doses to a patient being treated with phytonadione.
What other medicines interact with Vitamin k1?
MediHelp also lists interactions of Vitamin k1 with, for example, Warfarin, Cholestyramine, Colestipol. The full list is on the Vitamin k1 page.
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