Drug interactions
Sapropterin + Vardenafil
Severity: Minor
Sapropterin and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sapropterin may promote nitric oxide-mediated vasodilation, and vardenafil augments the nitric oxide-cGMP pathway. Together they could produce an additive blood pressure reduction, with dizziness or hypotension in susceptible patients. The clinical significance appears small.
What this interaction means in plain words
Sapropterin and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sapropterin belongs to Miscellaneous; Vardenafil belongs to Genitourinary.
Why it happens
Additive vasodilation through the nitric oxide/cGMP pathway (pharmacodynamic).
What to do
Monitor blood pressure and ask about dizziness when starting vardenafil in a patient on sapropterin. Counsel the patient to rise slowly and report symptoms of hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Sapropterin
- Avanafil + Sapropterin Moderate
- Carbidopa-entacapone-levodopa + Sapropterin Moderate
- Carbidopa-levodopa + Sapropterin Moderate
- Levodopa + Sapropterin Moderate
- Methotrexate + Sapropterin Moderate
- Phenobarbitone + Sapropterin Moderate
Frequently asked questions
Can I take Sapropterin with Vardenafil?
MediHelp rates the interaction as minor. Sapropterin and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sapropterin may promote nitric oxide-mediated vasodilation, and vardenafil augments the nitric oxide-cGMP pathway. Together they could produce an additive blood pressure reduction, with dizziness or hypotension in susceptible patients. The clinical significance appears small.
How serious is the interaction between Sapropterin and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ask about dizziness when starting vardenafil in a patient on sapropterin. Counsel the patient to rise slowly and report symptoms of hypotension.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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