Drug interactions
Sarecycline + Tolvaptan
Severity: Minor
Sarecycline and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is reported to inhibit P-glycoprotein in vitro, which could raise tolvaptan exposure. Systemic concentrations of sarecycline are low and the clinical importance is uncertain.
What this interaction means in plain words
Sarecycline and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sarecycline belongs to Anti Bacterial; Tolvaptan belongs to Endocrine.
Why it happens
Possible P-glycoprotein inhibition by sarecycline, increasing tolvaptan absorption.
What to do
No empirical dose change is required. Monitor serum sodium and volume status after starting sarecycline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Sarecycline with Tolvaptan?
MediHelp rates the interaction as minor. Sarecycline and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is reported to inhibit P-glycoprotein in vitro, which could raise tolvaptan exposure. Systemic concentrations of sarecycline are low and the clinical importance is uncertain.
How serious is the interaction between Sarecycline and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required. Monitor serum sodium and volume status after starting sarecycline.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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