Drug interactions
Sarilumab + Zoster vaccine recombinant
Severity: Minor
Sarilumab and Zoster vaccine recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive therapy may blunt the immune response to vaccination, so protection from the recombinant zoster vaccine may be reduced. Because the vaccine is non-live, it can be given safely, but its response may be suboptimal.
What this interaction means in plain words
Sarilumab and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
IL-6 blockade may reduce the immune response to vaccine antigens.
What to do
Give the recombinant vaccine, ideally before starting sarilumab or when disease is controlled, without delaying needed therapy. Do not rely on the vaccine alone and monitor for herpes zoster.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sarilumab
Frequently asked questions
Can I take Sarilumab with Zoster vaccine recombinant?
MediHelp rates the interaction as minor. Sarilumab and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Immunosuppressive therapy may blunt the immune response to vaccination, so protection from the recombinant zoster vaccine may be reduced. Because the vaccine is non-live, it can be given safely, but its response may be suboptimal.
How serious is the interaction between Sarilumab and Zoster vaccine recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the recombinant vaccine, ideally before starting sarilumab or when disease is controlled, without delaying needed therapy. Do not rely on the vaccine alone and monitor for herpes zoster.
What other medicines interact with Sarilumab?
MediHelp also lists interactions of Sarilumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Dengue vaccine. The full list is on the Sarilumab page.
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