Drug interactions
Saxagliptin + Somatropin
Severity: Moderate
Saxagliptin and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin can reduce insulin sensitivity and raise blood glucose, which may partly counteract the effect of saxagliptin. Glycemic control can worsen after growth hormone is started or the dose is increased.
What this interaction means in plain words
Saxagliptin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance and increases hepatic glucose output and lipolysis.
What to do
Monitor blood glucose and HbA1c when starting or adjusting somatropin. Intensify antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Saxagliptin with Somatropin?
MediHelp rates the interaction as moderate. Saxagliptin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin can reduce insulin sensitivity and raise blood glucose, which may partly counteract the effect of saxagliptin. Glycemic control can worsen after growth hormone is started or the dose is increased.
How serious is the interaction between Saxagliptin and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or adjusting somatropin. Intensify antidiabetic therapy if needed.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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