Drug interactions
Saxagliptin-metformin + Selegiline
Severity: Minor
Saxagliptin-metformin and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline has no well-established pharmacokinetic interaction with metformin or saxagliptin. MAO inhibitors may enhance the hypoglycemic effect of antidiabetic drugs, though risk is low with these agents.
What this interaction means in plain words
Saxagliptin-metformin and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin-metformin belongs to Endocrine; Selegiline belongs to Central Nervous System.
Why it happens
The mechanism is not well established; MAO inhibition may influence glucose regulation.
What to do
Monitor blood glucose when starting or stopping selegiline and adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Saxagliptin-metformin and Selegiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Saxagliptin-metformin
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Saxagliptin-metformin with Selegiline?
MediHelp rates the interaction as minor. Saxagliptin-metformin and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selegiline has no well-established pharmacokinetic interaction with metformin or saxagliptin. MAO inhibitors may enhance the hypoglycemic effect of antidiabetic drugs, though risk is low with these agents.
How serious is the interaction between Saxagliptin-metformin and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping selegiline and adjust antidiabetic doses if needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
