Drug interactions
Saxagliptin-metformin + Sotorasib
Severity: Minor
Saxagliptin-metformin and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib inhibits P-gp and may modestly raise saxagliptin exposure. Saxagliptin has a wide safety margin, so clinical impact is likely small.
What this interaction means in plain words
Saxagliptin-metformin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin-metformin belongs to Endocrine; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibits intestinal P-gp efflux of saxagliptin.
What to do
No dose change is usually needed; monitor glucose control and adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Saxagliptin-metformin with Sotorasib?
MediHelp rates the interaction as minor. Saxagliptin-metformin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib inhibits P-gp and may modestly raise saxagliptin exposure. Saxagliptin has a wide safety margin, so clinical impact is likely small.
How serious is the interaction between Saxagliptin-metformin and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor glucose control and adverse effects.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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