Drug interactions
Saxagliptin-metformin + Trandolapril
Severity: Moderate
Saxagliptin-metformin and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia with antidiabetic drugs. Renal function decline may also increase metformin accumulation and the risk of lactic acidosis. Angioedema risk may be additive with saxagliptin.
What this interaction means in plain words
Saxagliptin-metformin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin-metformin belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
Additive glucose lowering via improved insulin sensitivity, plus possible renal impairment reducing metformin clearance.
What to do
Monitor glucose and renal function after starting or adjusting trandolapril. Reduce antidiabetic doses if hypoglycemia occurs and review metformin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Saxagliptin-metformin with Trandolapril?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia with antidiabetic drugs. Renal function decline may also increase metformin accumulation and the risk of lactic acidosis. Angioedema risk may be additive with saxagliptin.
How serious is the interaction between Saxagliptin-metformin and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function after starting or adjusting trandolapril. Reduce antidiabetic doses if hypoglycemia occurs and review metformin if renal function declines.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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