Drug interactions
Saxagliptin-metformin + Triamterene
Severity: Moderate
Saxagliptin-metformin and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a cationic drug and may compete with metformin for renal tubular secretion, modestly raising metformin exposure. Triamterene may also impair renal function, which increases the risk of metformin accumulation.
What this interaction means in plain words
Saxagliptin-metformin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin-metformin belongs to Endocrine; Triamterene belongs to Cardiovascular.
Why it happens
Competition at renal cationic transporters (OCT2/MATE) reduces metformin clearance.
What to do
Monitor renal function and glucose control, and watch for signs of metformin toxicity; reduce the metformin dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Saxagliptin-metformin with Triamterene?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamterene is a cationic drug and may compete with metformin for renal tubular secretion, modestly raising metformin exposure. Triamterene may also impair renal function, which increases the risk of metformin accumulation.
How serious is the interaction between Saxagliptin-metformin and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and glucose control, and watch for signs of metformin toxicity; reduce the metformin dose if renal function declines.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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