Drug interactions
Saxagliptin-metformin + Vandetanib
Severity: Moderate
Saxagliptin-metformin and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits renal organic cation transporter 2, which participates in metformin tubular secretion. Metformin exposure may rise, with a possible increase in gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Saxagliptin-metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin-metformin belongs to Endocrine; Vandetanib belongs to Oncology.
Why it happens
Vandetanib inhibits OCT2-mediated renal uptake and secretion of metformin, reducing its clearance.
What to do
Monitor glycemic control and renal function, and watch for signs of metformin toxicity. Reduce the metformin dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Saxagliptin-metformin with Vandetanib?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib inhibits renal organic cation transporter 2, which participates in metformin tubular secretion. Metformin exposure may rise, with a possible increase in gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Saxagliptin-metformin and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function, and watch for signs of metformin toxicity. Reduce the metformin dose if adverse effects develop.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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