Drug interactions
Scopolamine + Tiotropium
Severity: Moderate
Scopolamine and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scopolamine is a potent antimuscarinic with central effects. With tiotropium, additive anticholinergic effects may cause dry mouth, urinary retention, blurred vision, drowsiness and confusion, especially in older adults.
What this interaction means in plain words
Scopolamine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Scopolamine belongs to Respiratory; Tiotropium belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects including confusion, urinary retention and visual symptoms. Avoid in patients with narrow-angle glaucoma and use the lowest effective scopolamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Scopolamine
Frequently asked questions
Can I take Scopolamine with Tiotropium?
MediHelp rates the interaction as moderate. Scopolamine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Scopolamine is a potent antimuscarinic with central effects. With tiotropium, additive anticholinergic effects may cause dry mouth, urinary retention, blurred vision, drowsiness and confusion, especially in older adults.
How serious is the interaction between Scopolamine and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects including confusion, urinary retention and visual symptoms. Avoid in patients with narrow-angle glaucoma and use the lowest effective scopolamine dose.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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