Drug interactions
Secobarbital + Tadalafil
Severity: Moderate
Secobarbital and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates such as secobarbital induce CYP3A4 and may reduce tadalafil exposure, leading to diminished therapeutic effect. The effect is most important in pulmonary arterial hypertension.
What this interaction means in plain words
Secobarbital and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secobarbital belongs to Central Nervous System; Tadalafil belongs to Genitourinary.
Why it happens
Enzyme induction of CYP3A4 increases tadalafil clearance.
What to do
Avoid in pulmonary arterial hypertension where possible. In erectile dysfunction, monitor response and consider a dose adjustment or alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Tadalafil?
MediHelp rates the interaction as moderate. Secobarbital and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates such as secobarbital induce CYP3A4 and may reduce tadalafil exposure, leading to diminished therapeutic effect. The effect is most important in pulmonary arterial hypertension.
How serious is the interaction between Secobarbital and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in pulmonary arterial hypertension where possible. In erectile dysfunction, monitor response and consider a dose adjustment or alternative.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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