Drug interactions
Secobarbital + Tolterodine
Severity: Minor
Secobarbital and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and may lower tolterodine concentrations, mainly in CYP2D6 poor metabolizers. Reduced efficacy is possible but generally modest.
What this interaction means in plain words
Secobarbital and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Secobarbital belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Enzyme induction by secobarbital increases CYP3A4 metabolism of tolterodine.
What to do
Monitor symptom control and adjust the tolterodine dose if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Tolterodine?
MediHelp rates the interaction as minor. Secobarbital and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce CYP3A4 and may lower tolterodine concentrations, mainly in CYP2D6 poor metabolizers. Reduced efficacy is possible but generally modest.
How serious is the interaction between Secobarbital and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and adjust the tolterodine dose if response is inadequate.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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