Drug interactions
Sertraline + Thioridazine
Severity: Contraindicated
Sertraline and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine causes dose-related QT prolongation, and sertraline may increase its exposure, raising the risk of torsades de pointes and sudden death. Sertraline itself has a modest QT effect, adding to the risk.
What this interaction means in plain words
Sertraline and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Sertraline belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Sertraline inhibits CYP2D6, the main route of thioridazine metabolism, and both drugs have additive QT-prolonging effects.
What to do
Do not use together. Choose an alternative antipsychotic or antidepressant, and allow adequate washout of sertraline before any thioridazine use.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Sertraline with Thioridazine?
MediHelp rates the interaction as contraindicated. Sertraline and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes dose-related QT prolongation, and sertraline may increase its exposure, raising the risk of torsades de pointes and sudden death. Sertraline itself has a modest QT effect, adding to the risk.
How serious is the interaction between Sertraline and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose an alternative antipsychotic or antidepressant, and allow adequate washout of sertraline before any thioridazine use.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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