Drug interactions
Selegiline + Sparsentan
Severity: Minor
Selegiline and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP2B6 and may lower selegiline exposure, since CYP2B6 contributes to selegiline metabolism. The result could be reduced efficacy.
What this interaction means in plain words
Selegiline and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Selegiline belongs to Central Nervous System; Sparsentan belongs to Genitourinary.
Why it happens
CYP2B6 induction by sparsentan, increasing selegiline clearance.
What to do
Monitor clinical response to selegiline and increase the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Selegiline with Sparsentan?
MediHelp rates the interaction as minor. Selegiline and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sparsentan induces CYP2B6 and may lower selegiline exposure, since CYP2B6 contributes to selegiline metabolism. The result could be reduced efficacy.
How serious is the interaction between Selegiline and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to selegiline and increase the dose if needed.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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