Drug interactions
Selegiline + Sufentanil
Severity: Major
Selegiline and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioid analgesics given with MAO inhibitors can produce serotonin toxicity or excessive CNS and respiratory depression with hypotension. Risk is highest with transdermal or higher-dose selegiline.
What this interaction means in plain words
Selegiline and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Selegiline belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Possible serotonergic and CNS depressant potentiation with MAO inhibition; mechanism not fully defined.
What to do
Avoid where possible, and use reduced doses with careful titration if essential. Monitor respiration, blood pressure, temperature and mental status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Selegiline with Sufentanil?
MediHelp rates the interaction as major. Selegiline and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioid analgesics given with MAO inhibitors can produce serotonin toxicity or excessive CNS and respiratory depression with hypotension. Risk is highest with transdermal or higher-dose selegiline.
How serious is the interaction between Selegiline and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible, and use reduced doses with careful titration if essential. Monitor respiration, blood pressure, temperature and mental status.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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