Drug interactions
Selegiline + Sumatriptan
Severity: Moderate
Selegiline and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sumatriptan is metabolized by MAO-A, and MAO inhibition may raise its exposure. Together with additive serotonergic effects, this carries a risk of serotonin syndrome, mainly when selegiline loses selectivity at higher doses.
What this interaction means in plain words
Selegiline and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selegiline belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Reduced MAO-A metabolism of sumatriptan and additive serotonergic effects.
What to do
Use the lowest effective sumatriptan dose and counsel on serotonin syndrome symptoms. Avoid the combination with transdermal or higher-dose selegiline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Selegiline with Sumatriptan?
MediHelp rates the interaction as moderate. Selegiline and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sumatriptan is metabolized by MAO-A, and MAO inhibition may raise its exposure. Together with additive serotonergic effects, this carries a risk of serotonin syndrome, mainly when selegiline loses selectivity at higher doses.
How serious is the interaction between Selegiline and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sumatriptan dose and counsel on serotonin syndrome symptoms. Avoid the combination with transdermal or higher-dose selegiline.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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