Drug interactions
Selegiline + Tolcapone
Severity: Minor
Selegiline and Tolcapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolcapone can be combined with selegiline at standard doses, as selective MAO-B inhibition leaves catecholamine metabolism via MAO-A intact. Both increase dopaminergic effect, so additive dopaminergic adverse effects may occur.
What this interaction means in plain words
Selegiline and Tolcapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Selegiline belongs to Central Nervous System; Tolcapone belongs to Central Nervous System.
Why it happens
Complementary inhibition of COMT and MAO-B enhances dopaminergic activity without blocking both major catecholamine pathways.
What to do
Keep selegiline at doses selective for MAO-B (not above the recommended daily dose). Monitor for dyskinesia, nausea and orthostasis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Tolcapone?
MediHelp rates the interaction as minor. Selegiline and Tolcapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolcapone can be combined with selegiline at standard doses, as selective MAO-B inhibition leaves catecholamine metabolism via MAO-A intact. Both increase dopaminergic effect, so additive dopaminergic adverse effects may occur.
How serious is the interaction between Selegiline and Tolcapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep selegiline at doses selective for MAO-B (not above the recommended daily dose). Monitor for dyskinesia, nausea and orthostasis.
What other medicines interact with Tolcapone?
MediHelp also lists interactions of Tolcapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Tolcapone page.
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