Drug interactions
Selegiline + Umeclidinium-vilanterol
Severity: Moderate
Selegiline and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO-B inhibitor that at higher doses loses selectivity, which could potentiate cardiovascular effects of beta-agonists such as increased heart rate and blood pressure. Risk is greater with the oral, higher-dose forms.
What this interaction means in plain words
Selegiline and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selegiline belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Potential potentiation of adrenergic effects through reduced catecholamine breakdown.
What to do
Monitor blood pressure and heart rate, and avoid exceeding recommended selegiline doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Selegiline and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is an MAO-B inhibitor that at higher doses loses selectivity, which could potentiate cardiovascular effects of beta-agonists such as increased heart rate and blood pressure. Risk is greater with the oral, higher-dose forms.
How serious is the interaction between Selegiline and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and avoid exceeding recommended selegiline doses.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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