Drug interactions
Selegiline + Ziprasidone
Severity: Moderate
Selegiline and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO-B inhibitor that can become non-selective at higher doses, and combined with ziprasidone there is a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome. Ziprasidone also blocks dopamine receptors and may counteract selegiline's dopaminergic benefit in Parkinson's disease.
What this interaction means in plain words
Selegiline and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selegiline belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Opposing dopaminergic effects and possible additive serotonergic activity; largely theoretical.
What to do
Monitor for worsening motor symptoms and for signs of serotonin toxicity or neuroleptic malignant syndrome; consider an antipsychotic with less dopamine blockade in Parkinson's disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Ziprasidone?
MediHelp rates the interaction as moderate. Selegiline and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is an MAO-B inhibitor that can become non-selective at higher doses, and combined with ziprasidone there is a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome. Ziprasidone also blocks dopamine receptors and may counteract selegiline's dopaminergic benefit in Parkinson's disease.
How serious is the interaction between Selegiline and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening motor symptoms and for signs of serotonin toxicity or neuroleptic malignant syndrome; consider an antipsychotic with less dopamine blockade in Parkinson's disease.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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