Drug interactions
Selegiline transdermal + Zolmitriptan
Severity: Major
Selegiline transdermal and Zolmitriptan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal selegiline at antidepressant doses inhibits MAO-A and MAO-B, and zolmitriptan's active metabolite is cleared by MAO-A. Levels of the triptan metabolite can rise and serotonin syndrome becomes a concern.
What this interaction means in plain words
Selegiline transdermal and Zolmitriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO-A inhibition reduces zolmitriptan metabolite clearance, plus additive serotonergic effects.
What to do
Avoid the combination; zolmitriptan labeling advises against use with MAO-A inhibitors or within two weeks of stopping them. Choose a non-serotonergic migraine therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Selegiline transdermal and Zolmitriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Selegiline transdermal with Zolmitriptan?
MediHelp rates the interaction as major. Selegiline transdermal and Zolmitriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Transdermal selegiline at antidepressant doses inhibits MAO-A and MAO-B, and zolmitriptan's active metabolite is cleared by MAO-A. Levels of the triptan metabolite can rise and serotonin syndrome becomes a concern.
How serious is the interaction between Selegiline transdermal and Zolmitriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; zolmitriptan labeling advises against use with MAO-A inhibitors or within two weeks of stopping them. Choose a non-serotonergic migraine therapy.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
