Drug interactions
Selexipag + Sunitinib
Severity: Minor
Selexipag and Sunitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib may inhibit BCRP and raise exposure of selexipag or its active metabolite. This could increase prostacyclin-related effects such as headache, hypotension and diarrhea.
What this interaction means in plain words
Selexipag and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Selexipag belongs to Cardiovascular; Sunitinib belongs to Oncology.
Why it happens
Possible inhibition of BCRP-mediated efflux of selexipag by sunitinib.
What to do
Monitor for prostacyclin-related adverse effects and blood pressure, reducing selexipag dose if poorly tolerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Selexipag with Sunitinib?
MediHelp rates the interaction as minor. Selexipag and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sunitinib may inhibit BCRP and raise exposure of selexipag or its active metabolite. This could increase prostacyclin-related effects such as headache, hypotension and diarrhea.
How serious is the interaction between Selexipag and Sunitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for prostacyclin-related adverse effects and blood pressure, reducing selexipag dose if poorly tolerated.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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