Drug interactions
Selexipag + Tamoxifen
Severity: Moderate
Selexipag and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selexipag is converted to its active metabolite by carboxylesterases, and the metabolite is cleared by CYP2C8. Tamoxifen may inhibit CYP2C8, possibly increasing active metabolite exposure and prostacyclin-type adverse effects such as headache, flushing and hypotension.
What this interaction means in plain words
Selexipag and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selexipag belongs to Cardiovascular; Tamoxifen belongs to Endocrine.
Why it happens
CYP2C8 inhibition reduces clearance of selexipag's active metabolite.
What to do
Monitor for prostacyclin-related adverse effects and consider once-daily selexipag dosing as recommended for moderate CYP2C8 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Selexipag and Tamoxifen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Selexipag with Tamoxifen?
MediHelp rates the interaction as moderate. Selexipag and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selexipag is converted to its active metabolite by carboxylesterases, and the metabolite is cleared by CYP2C8. Tamoxifen may inhibit CYP2C8, possibly increasing active metabolite exposure and prostacyclin-type adverse effects such as headache, flushing and hypotension.
How serious is the interaction between Selexipag and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for prostacyclin-related adverse effects and consider once-daily selexipag dosing as recommended for moderate CYP2C8 inhibitors.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
