Drug interactions
Selinexor + Zolpidem
Severity: Moderate
Selinexor and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and fatigue, and zolpidem may add to these CNS effects, raising the risk of falls and impaired cognition.
What this interaction means in plain words
Selinexor and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selinexor belongs to Oncology; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS adverse effects; no pharmacokinetic mechanism established.
What to do
Minimize or avoid zolpidem when possible and monitor for confusion, dizziness and falls, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Selinexor with Zolpidem?
MediHelp rates the interaction as moderate. Selinexor and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and fatigue, and zolpidem may add to these CNS effects, raising the risk of falls and impaired cognition.
How serious is the interaction between Selinexor and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Minimize or avoid zolpidem when possible and monitor for confusion, dizziness and falls, especially in older patients.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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