Drug interactions
Selpercatinib + Sertraline
Severity: Moderate
Selpercatinib and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and sertraline may add to this effect. The combination may raise the risk of torsades de pointes, particularly with electrolyte disturbances.
What this interaction means in plain words
Selpercatinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selpercatinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarisation.
What to do
Monitor ECG and electrolytes at baseline and periodically, correcting low potassium or magnesium. Reduce or interrupt selpercatinib if QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Selpercatinib with Sertraline?
MediHelp rates the interaction as moderate. Selpercatinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, and sertraline may add to this effect. The combination may raise the risk of torsades de pointes, particularly with electrolyte disturbances.
How serious is the interaction between Selpercatinib and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, correcting low potassium or magnesium. Reduce or interrupt selpercatinib if QTc becomes significantly prolonged.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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