Drug interactions
Selpercatinib + Simvastatin
Severity: Major
Selpercatinib and Simvastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib may raise simvastatin plasma concentrations, increasing the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Selpercatinib and Simvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Selpercatinib belongs to Oncology; Simvastatin belongs to Cardiovascular.
Why it happens
Selpercatinib inhibits CYP3A4, which is the main route of simvastatin metabolism.
What to do
Avoid the combination and switch to a statin less dependent on CYP3A4, such as rosuvastatin or pravastatin. If unavoidable, use the lowest simvastatin dose and monitor for muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Selpercatinib and Simvastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Selpercatinib
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Selpercatinib with Simvastatin?
MediHelp rates the interaction as major. Selpercatinib and Simvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selpercatinib may raise simvastatin plasma concentrations, increasing the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Selpercatinib and Simvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and switch to a statin less dependent on CYP3A4, such as rosuvastatin or pravastatin. If unavoidable, use the lowest simvastatin dose and monitor for muscle symptoms.
What other medicines interact with Selpercatinib?
MediHelp also lists interactions of Selpercatinib with, for example, Amiodarone, Amisulpride, Amitriptyline. The full list is on the Selpercatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
