Drug interactions
Selpercatinib + Vardenafil
Severity: Moderate
Selpercatinib and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so the combination may raise the risk of ventricular arrhythmias. Selpercatinib is also a weak CYP3A4 inhibitor that may modestly increase vardenafil exposure.
What this interaction means in plain words
Selpercatinib and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selpercatinib belongs to Oncology; Vardenafil belongs to Genitourinary.
Why it happens
Additive QT prolongation with possible mild CYP3A4 inhibition by selpercatinib.
What to do
Monitor ECG and electrolytes, and correct potassium and magnesium abnormalities. Use the lowest effective vardenafil dose in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Selpercatinib with Vardenafil?
MediHelp rates the interaction as moderate. Selpercatinib and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so the combination may raise the risk of ventricular arrhythmias. Selpercatinib is also a weak CYP3A4 inhibitor that may modestly increase vardenafil exposure.
How serious is the interaction between Selpercatinib and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and correct potassium and magnesium abnormalities. Use the lowest effective vardenafil dose in patients with cardiac risk factors.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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