Drug interactions
Selumetinib + Voriconazole
Severity: Major
Selumetinib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole strongly inhibits CYP3A4, the main enzyme clearing selumetinib, so selumetinib exposure rises. This can increase adverse effects such as gastrointestinal toxicity, rash, and cardiac effects including reduced ejection fraction.
What this interaction means in plain words
Selumetinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Selumetinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of selumetinib, reducing its clearance.
What to do
Prefer an antifungal that does not inhibit CYP3A4 strongly. If unavoidable, reduce the selumetinib dose per labeling and restore the prior dose about 3 half-lives after stopping voriconazole.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Selumetinib
Frequently asked questions
Can I take Selumetinib with Voriconazole?
MediHelp rates the interaction as major. Selumetinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole strongly inhibits CYP3A4, the main enzyme clearing selumetinib, so selumetinib exposure rises. This can increase adverse effects such as gastrointestinal toxicity, rash, and cardiac effects including reduced ejection fraction.
How serious is the interaction between Selumetinib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antifungal that does not inhibit CYP3A4 strongly. If unavoidable, reduce the selumetinib dose per labeling and restore the prior dose about 3 half-lives after stopping voriconazole.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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