Drug interactions
Sertraline + Sorafenib
Severity: Moderate
Sertraline and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, and sertraline may add a small effect. The risk is mainly relevant in patients with other arrhythmia risk factors.
What this interaction means in plain words
Sertraline and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Check ECG and electrolytes at baseline and periodically in patients with cardiac risk factors. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Sertraline with Sorafenib?
MediHelp rates the interaction as moderate. Sertraline and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can prolong the QT interval, and sertraline may add a small effect. The risk is mainly relevant in patients with other arrhythmia risk factors.
How serious is the interaction between Sertraline and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and periodically in patients with cardiac risk factors. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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