Drug interactions
Sertraline + Suvorexant
Severity: Minor
Sertraline and Suvorexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline weakly inhibits CYP3A4, which may modestly increase suvorexant exposure. This may increase next-day somnolence and impaired psychomotor performance. Both drugs may also add to CNS effects.
What this interaction means in plain words
Sertraline and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sertraline belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline plus additive CNS effects.
What to do
Start suvorexant at the lowest dose and counsel about next-day drowsiness and driving. Increase the dose only if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Sertraline with Suvorexant?
MediHelp rates the interaction as minor. Sertraline and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline weakly inhibits CYP3A4, which may modestly increase suvorexant exposure. This may increase next-day somnolence and impaired psychomotor performance. Both drugs may also add to CNS effects.
How serious is the interaction between Sertraline and Suvorexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start suvorexant at the lowest dose and counsel about next-day drowsiness and driving. Increase the dose only if needed.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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