Drug interactions
Sertraline + Timolol
Severity: Minor
Sertraline and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is a mild to moderate CYP2D6 inhibitor and may modestly increase timolol exposure, with possible bradycardia or hypotension. The effect is usually small at low sertraline doses.
What this interaction means in plain words
Sertraline and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sertraline belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Dose-dependent CYP2D6 inhibition by sertraline reduces timolol metabolism.
What to do
Monitor heart rate and blood pressure after sertraline is started or the dose increased. Reduce the timolol dose only if bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Timolol?
MediHelp rates the interaction as minor. Sertraline and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline is a mild to moderate CYP2D6 inhibitor and may modestly increase timolol exposure, with possible bradycardia or hypotension. The effect is usually small at low sertraline doses.
How serious is the interaction between Sertraline and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after sertraline is started or the dose increased. Reduce the timolol dose only if bradycardia or hypotension occurs.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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