Drug interactions
Sertraline + Tolmetin
Severity: Moderate
Sertraline and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as sertraline deplete platelet serotonin and, with an NSAID, markedly increase the risk of upper gastrointestinal bleeding. The risk is higher in older patients and those with prior ulcers or anticoagulant use.
What this interaction means in plain words
Sertraline and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive impairment of platelet aggregation (SSRI serotonin depletion plus NSAID COX inhibition) together with NSAID mucosal injury.
What to do
Avoid long-term combined use where possible; if needed, add a proton pump inhibitor for gastroprotection and use the lowest NSAID dose. Monitor for GI bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Tolmetin?
MediHelp rates the interaction as moderate. Sertraline and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs such as sertraline deplete platelet serotonin and, with an NSAID, markedly increase the risk of upper gastrointestinal bleeding. The risk is higher in older patients and those with prior ulcers or anticoagulant use.
How serious is the interaction between Sertraline and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combined use where possible; if needed, add a proton pump inhibitor for gastroprotection and use the lowest NSAID dose. Monitor for GI bleeding signs.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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