Drug interactions
Sertraline + Tolterodine
Severity: Minor
Sertraline and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is a mild to moderate, dose-dependent CYP2D6 inhibitor and may slightly increase tolterodine levels. Overall impact is limited because CYP3A4 provides an alternative clearance route.
What this interaction means in plain words
Sertraline and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sertraline belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Inhibition of CYP2D6-mediated metabolism of tolterodine by sertraline.
What to do
No routine adjustment is needed; monitor for anticholinergic effects, particularly at higher sertraline doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Tolterodine?
MediHelp rates the interaction as minor. Sertraline and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline is a mild to moderate, dose-dependent CYP2D6 inhibitor and may slightly increase tolterodine levels. Overall impact is limited because CYP3A4 provides an alternative clearance route.
How serious is the interaction between Sertraline and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for anticholinergic effects, particularly at higher sertraline doses.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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