Drug interactions
Sertraline + Zuranolone
Severity: Moderate
Sertraline and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes sedation, somnolence and impaired psychomotor performance, and other CNS-active drugs such as sertraline may add to these effects. Patients may have impaired driving ability and daytime drowsiness.
What this interaction means in plain words
Sertraline and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through GABA-A positive modulation and sertraline's CNS effects.
What to do
Consider reducing the zuranolone dose if excessive sedation occurs. Warn patients not to drive or operate machinery for at least 12 hours after each dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Sertraline with Zuranolone?
MediHelp rates the interaction as moderate. Sertraline and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes sedation, somnolence and impaired psychomotor performance, and other CNS-active drugs such as sertraline may add to these effects. Patients may have impaired driving ability and daytime drowsiness.
How serious is the interaction between Sertraline and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose if excessive sedation occurs. Warn patients not to drive or operate machinery for at least 12 hours after each dose.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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