Drug interactions
Sildenafil + Tipranavir
Severity: Major
Sildenafil and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, inhibits CYP3A4 and may increase sildenafil exposure. This raises the risk of hypotension, syncope, visual changes and priapism.
What this interaction means in plain words
Sildenafil and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sildenafil belongs to Genitourinary; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4, reducing the metabolic clearance of sildenafil, although tipranavir also has some inducing effects.
What to do
Start sildenafil at a low dose (for example 25 mg, not more than once every 48 hours) for erectile dysfunction and monitor blood pressure and adverse effects. Avoid use for pulmonary arterial hypertension unless specifically advised by labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Sildenafil with Tipranavir?
MediHelp rates the interaction as major. Sildenafil and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, given with ritonavir, inhibits CYP3A4 and may increase sildenafil exposure. This raises the risk of hypotension, syncope, visual changes and priapism.
How serious is the interaction between Sildenafil and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sildenafil at a low dose (for example 25 mg, not more than once every 48 hours) for erectile dysfunction and monitor blood pressure and adverse effects. Avoid use for pulmonary arterial hypertension unless specifically advised by labeling.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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