Drug interactions
Simvastatin + Tolvaptan
Severity: Minor
Simvastatin and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Simvastatin is a weak P-glycoprotein inhibitor and could modestly raise exposure to tolvaptan, a P-glycoprotein substrate. The clinical significance is likely small.
What this interaction means in plain words
Simvastatin and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Simvastatin belongs to Cardiovascular; Tolvaptan belongs to Endocrine.
Why it happens
Possible weak inhibition of P-glycoprotein efflux of tolvaptan by simvastatin.
What to do
No routine adjustment is needed. Monitor serum sodium and volume status as usual during tolvaptan therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Simvastatin with Tolvaptan?
MediHelp rates the interaction as minor. Simvastatin and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Simvastatin is a weak P-glycoprotein inhibitor and could modestly raise exposure to tolvaptan, a P-glycoprotein substrate. The clinical significance is likely small.
How serious is the interaction between Simvastatin and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor serum sodium and volume status as usual during tolvaptan therapy.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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