Drug interactions
Simvastatin + Valsartan
Severity: Minor
Simvastatin and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is taken up into hepatocytes by OATP1B1 in laboratory studies. Simvastatin (mainly its acid form) can interact with this transporter, so valsartan exposure could rise in theory. Clinical significance is uncertain and no meaningful effect has been established.
What this interaction means in plain words
Simvastatin and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Simvastatin belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Possible competition at hepatic OATP1B1 uptake, derived from in vitro data and not confirmed clinically.
What to do
No routine dose change is needed; monitor blood pressure and watch for hypotension or ARB adverse effects if either drug is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Simvastatin with Valsartan?
MediHelp rates the interaction as minor. Simvastatin and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is taken up into hepatocytes by OATP1B1 in laboratory studies. Simvastatin (mainly its acid form) can interact with this transporter, so valsartan exposure could rise in theory. Clinical significance is uncertain and no meaningful effect has been established.
How serious is the interaction between Simvastatin and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor blood pressure and watch for hypotension or ARB adverse effects if either drug is started or stopped.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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