Drug interactions
Simvastatin + Vincristine
Severity: Minor
Simvastatin and Vincristine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Simvastatin may inhibit P-glycoprotein and theoretically increase vincristine exposure, which could worsen peripheral neuropathy or constipation. The effect is predicted rather than well documented.
What this interaction means in plain words
Simvastatin and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Simvastatin belongs to Cardiovascular; Vincristine belongs to Oncology.
Why it happens
Theoretical P-glycoprotein inhibition by simvastatin reducing vincristine efflux.
What to do
No empirical change is needed. Monitor for neurotoxicity and constipation as in standard vincristine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Simvastatin with Vincristine?
MediHelp rates the interaction as minor. Simvastatin and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Simvastatin may inhibit P-glycoprotein and theoretically increase vincristine exposure, which could worsen peripheral neuropathy or constipation. The effect is predicted rather than well documented.
How serious is the interaction between Simvastatin and Vincristine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical change is needed. Monitor for neurotoxicity and constipation as in standard vincristine care.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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