Drug interactions
Siponimod + Sparsentan
Severity: Moderate
Siponimod and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod is cleared mainly by CYP2C9, and sparsentan is a CYP2C9 inducer. Co-administration may lower siponimod exposure and reduce its effectiveness.
What this interaction means in plain words
Siponimod and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Siponimod belongs to Central Nervous System; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan induces CYP2C9, increasing siponimod metabolism.
What to do
Monitor for loss of multiple sclerosis disease control. Confirm the patient's CYP2C9 genotype is compatible with siponimod and consider alternatives if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Siponimod with Sparsentan?
MediHelp rates the interaction as moderate. Siponimod and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod is cleared mainly by CYP2C9, and sparsentan is a CYP2C9 inducer. Co-administration may lower siponimod exposure and reduce its effectiveness.
How serious is the interaction between Siponimod and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of multiple sclerosis disease control. Confirm the patient's CYP2C9 genotype is compatible with siponimod and consider alternatives if efficacy declines.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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