Drug interactions
Siponimod + Vardenafil
Severity: Moderate
Siponimod and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod can slow heart rate and prolong conduction, and vardenafil has a modest QT effect. Combined use may increase the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Siponimod and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Siponimod belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Additive effects on cardiac conduction and repolarization.
What to do
Obtain a baseline ECG and monitor heart rate and QTc, especially at siponimod initiation. Avoid the combination in patients with QT prolongation or significant bradyarrhythmia risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Siponimod with Vardenafil?
MediHelp rates the interaction as moderate. Siponimod and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod can slow heart rate and prolong conduction, and vardenafil has a modest QT effect. Combined use may increase the risk of arrhythmia in susceptible patients.
How serious is the interaction between Siponimod and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and QTc, especially at siponimod initiation. Avoid the combination in patients with QT prolongation or significant bradyarrhythmia risk.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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