Drug interactions
Siponimod + Venetoclax
Severity: Moderate
Siponimod and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venetoclax commonly causes neutropenia, and siponimod reduces circulating lymphocytes. Combined use may increase the risk of serious infections.
What this interaction means in plain words
Siponimod and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Siponimod belongs to Central Nervous System; Venetoclax belongs to Miscellaneous.
Why it happens
Additive immunosuppressive and myelosuppressive effects.
What to do
Monitor blood counts and for infection during co-therapy. Interrupt or adjust venetoclax per its labeling for neutropenia, and consider holding siponimod during serious infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Siponimod with Venetoclax?
MediHelp rates the interaction as moderate. Siponimod and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venetoclax commonly causes neutropenia, and siponimod reduces circulating lymphocytes. Combined use may increase the risk of serious infections.
How serious is the interaction between Siponimod and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for infection during co-therapy. Interrupt or adjust venetoclax per its labeling for neutropenia, and consider holding siponimod during serious infection.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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