Drug interactions
Sipuleucel-t + Tacrolimus
Severity: Moderate
Sipuleucel-t and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sipuleucel-T works by stimulating the patient's own immune cells, and immunosuppressants such as tacrolimus may reduce this effect. Treatment efficacy could be diminished.
What this interaction means in plain words
Sipuleucel-t and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition by tacrolimus suppresses T-cell activation and antigen-presenting cell responses needed for the immunotherapy.
What to do
Avoid immunosuppressants around sipuleucel-T collection and infusion if possible. If tacrolimus is essential, weigh the likely reduced benefit of the vaccine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Sipuleucel-t with Tacrolimus?
MediHelp rates the interaction as moderate. Sipuleucel-t and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sipuleucel-T works by stimulating the patient's own immune cells, and immunosuppressants such as tacrolimus may reduce this effect. Treatment efficacy could be diminished.
How serious is the interaction between Sipuleucel-t and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid immunosuppressants around sipuleucel-T collection and infusion if possible. If tacrolimus is essential, weigh the likely reduced benefit of the vaccine.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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