Drug interactions
Sirolimus + Sofosbuvir / velpatasvir
Severity: Moderate
Sirolimus and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits P-glycoprotein and may raise sirolimus concentrations. Higher levels can increase sirolimus toxicity, and hepatitis C treatment can also alter liver function and drug metabolism.
What this interaction means in plain words
Sirolimus and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal P-glycoprotein and possibly CYP3A4 by velpatasvir reduces sirolimus efflux and clearance.
What to do
Monitor sirolimus trough concentrations during and after the hepatitis C treatment course. Reduce the sirolimus dose if levels rise above target.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Sirolimus and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits P-glycoprotein and may raise sirolimus concentrations. Higher levels can increase sirolimus toxicity, and hepatitis C treatment can also alter liver function and drug metabolism.
How serious is the interaction between Sirolimus and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations during and after the hepatitis C treatment course. Reduce the sirolimus dose if levels rise above target.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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