Drug interactions
Sirolimus + Somatropin
Severity: Minor
Sirolimus and Somatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP3A4 activity and could lower sirolimus concentrations. Because sirolimus has a narrow therapeutic range, even small changes could matter in transplant recipients.
What this interaction means in plain words
Sirolimus and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sirolimus belongs to Miscellaneous; Somatropin belongs to Endocrine.
Why it happens
Possible growth hormone-mediated induction of CYP3A4, based on limited data.
What to do
Measure sirolimus trough levels after somatropin is started or stopped and adjust the dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Somatropin?
MediHelp rates the interaction as minor. Sirolimus and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase CYP3A4 activity and could lower sirolimus concentrations. Because sirolimus has a narrow therapeutic range, even small changes could matter in transplant recipients.
How serious is the interaction between Sirolimus and Somatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure sirolimus trough levels after somatropin is started or stopped and adjust the dose accordingly.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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